Transmission and compression of genetic data

Patent No. 8,812,243

Issued: August 19, 2014
Filed: May 19, 2012

Inventors: Cardonha; Carlos H. (Sao Paulo, BR), Friedlander; Robert R. (Southbury, CT), Herrmann; Ricardo G. (Sao Paulo, BR), Kraemer; James R. (Santa Fe, NM), Nogima; Julio (Londrina, BR)
Assignee: International Business Machines Corporation (Armonk, NY)


A method, computer product and computer system of transmitting a compressed genome of an organism: a computer at a source reading an uncompressed sequence and a reference genome from a repository; the computer comparing nucleotides of the genetic sequence of the organism to nucleotides from a reference genome, to find differences where nucleotides of the genetic sequence of the organism which are different from the nucleotides of the reference genome; the computer using the differences to create surprisal data, the surprisal data comprising a starting location of the differences within the reference genome, and the nucleotides from the genetic sequence of the organism which are different from the nucleotides of the reference genome; and the computer transmitting, to a destination, a compressed genome comprising: surprisal data and an indication of the reference genome, discarding sequences of nucleotides that are the same in the sequence of the organism and reference genome.


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