Method for the rapid diagnosis of targets in human body fluids
Patent No. 7,723,124
Issued: May 25, 2010
Inventors: Aberl; Franz (Princeton, NJ), Scheibenzuber; Marcus (Munich, DE), Sambursky; Robert F. (Philadelphia, PA), Vandine; Robert W. (Montoursville, PA), Sambursky; Jose S. (Johnson City, NY)
Assignee: Rapid Pathogen Screening, Inc. (Sarasota, FL)
The invention provides a sensitive and rapid method for the detection of
targets, e.g. pathogens and/or allergy-associated components in samples
collected by non-invasive means from a body fluid. The pathogens are selected
from viruses, microorganisms, e.g. bacteria and parasites, e.g. amoebae or
nematodes. The allergy-associated components are selected from allergens and
anti-allergic components. The detection may comprise a direct detection of the
target, e.g. the pathogen and/or the detection of antibodies against the target,
e.g. the pathogen which are present in the fluid sample to be tested.
Preferably, the method comprises a parallel determination of a plurality of
The body fluid is preferably a fluid from a body surface selected from mucose membrane fluids (of the oral, nasal, vaginal, and ocular cavities) tears, secretions from glands and secretions from lesions or blisters, e.g. lesions or blisters on the skin. More preferably, the sample is selected from oral, nasal, ocular, genital and rectal fluids and secretions from skin lesions or blisters. Most preferably, the sample is an eye fluid. A significant advantage of the method is that results are provided within the medical consultation period, e.g. in few minutes. Preferably, the results are provided in a time period up to 20 minutes, more preferably up to 15 minutes. Also, as the test is noninvasive, it poses very little risk to the patient. Thus the best available treatment can be applied on a timely basis for a specific pathogen. A further advantage over prior art methods is that only a few microliters of sample are required to perform an analysis. The sample is preferably about 0.1 .mu.l to about 100 .mu.l, more preferably about 0.2 .mu.l to about 20 .mu.l and most preferably about 0.5 .mu.l to about 10 .mu.l.
Reference to Related Applications
This application claims the benefit of U.S. Provisional Application No. 60/542,303, filed Feb. 9, 2004.
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