Patent number: 7294348

Polyfunctional biocompatible hydrogel and method for the production thereof

Original Assignee: Biopharma Development, Ltd.

Field of technology: Biotech

Patent granted on: Tue, 13 Nov 2007

Patent drawing

Abstract

The inventive polyfunctional biocompatible hydrogel comprises 1.3–15 mass % of acrylamide, 0.004–0.975 mass % of cross-linking agents—N,N′-methylen-bis-acrylamide, 0.004–5.1 mass % of N,N′-ethylen-bis-acrylamide, 0.002–0.45 mass % of poviargol and water up to 100 mass %. Said hydrogel is produced by sopolymerising acrylamide with the cross-linking agents in an aqueous medium in the presence of peroxide polymerisation initiator, the incubation of reaction mixture being carried out in two stages. The first stage is carried out at a temperature ranging from 20 to 90° C. during a time of 2 to 24 hours, the second stage being carried out at a temperature ranging from 107 to 130° C. during a time equal to or less than 2 hours.