Patent number: 6261805
Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
Original Assignee: Boyce Thompson Institute for Plant Research, Inc.
Field of technology: Biotech
Patent granted on: Tue, 17 Jul 2001
Abstract
The present disclosure utilizes a novel approach to protein preparation in the baculovirus expression vector system (BEVS). Specifically, the present invention analyzes the effects of microgravity/low shear on complex glycosylation of proteins prepared via BEVS, including the addition of terminal sialic acid residues to N-linked oligosaccharides.